Preclinical models of non-alcoholic steatohepatitis – BioTechniques

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Non-alcoholic steatohepatitis (NASH) is a condition in which fat accumulates in the liver in people who drink little or no alcohol. Despite widespread R&D effort, no regulatory approved therapeutic drugs are available, because traditional preclinical models fail to predict the efficacy of potential drugs in humans.
In this infographic, we compare four preclinical NASH models: in vitro 2D models, in vitro 3D spheroid models, in vivo animal models and in vitro organ-on-a-chip models, highlighting the pros and cons of each.



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Illustration by Hannah Morton.
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